Human XCL1 l is a unique metamorphic chemokine that interconverts between two distinct conformations under physiological conditions. In one conformation, XCL1 exists as a monomer and is able to bind to and activate its receptor XCR1. In the other conformation, XCL1 exists as a dimer and loses affinity for XCR1. XCL1 is an inflammatory chemokine that is produced by activated CD8+ T cells and natural killer cells. It is involved in the mediation of interactions between antigen-presenting dendritic cells and T-cells, and induction of CD8+ effector T-cell responses.
| Purity|| Assessed by HPLC, Mass Spectrometry, and NMR |
| Source|| Human protein expressed in E. coli|
| Physical form|| Lyophilized powder|
| Solubility|| Freely Soluble in Water|
| Accession #|| P47992.1|
| N-terminal analysis || Val22|
| Endotoxin level|| <0.01 EU per 1µg of the protein by LAL method|