Human CXCL8 is a 77 amino acid protein that is the prototypical CXC chemokine which is expressed by fibroblasts and keratinocytes. Also known as Interleukin 8, this chemokine binds and activates two G protein-coupled receptors, CXCR1/CXCR2 on a variety of cells such as neutrophils, T-cells, endothelial cells, macrophages and keratinocytes. CXCL8 is N-terminally processed to yield the major in vivo species, the 6-77 variant.
Amino Acid Sequence:
SAKELRCQCI KTYSKPFHPK FIKELRVIES GPHCANTEII VKLSDGRELC LDPKENWVQR VVEKFLKRAE NS
Molecular Weight:
8,381.8 Daltons
Purity:
Purity assessed by HPLC, Mass Spectrometry, and NMR*
Source:
Human protein expressed in E. coli
Physical Form:
Lyophilized
Solubility:
Freely soluble in water **
Storage Conditions:
Product Form
Temperature
Storage Time
-20C to -80C
12 months
4C
6 months
RT
1 month
Additional comments or descriptive information:
* All recombinant proteins produced and sold by Protein Foundry, LLC are endotoxin-free <0.01 EU/ug of protein and validated using RP-HPLC, 2D-NMR, and functional reporter assay where available.
** Avoid repeated freeze-thaw cycles after reconstitution
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