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Human CXCL8 is a 77 amino acid protein that is the prototypical CXC chemokine which is expressed by fibroblasts and keratinocytes. Also known as Interleukin 8, this chemokine binds and activates two G protein-coupled receptors, CXCR1/CXCR2 on a variety of cells such as neutrophils, T-cells, endothelial cells, macrophages and keratinocytes. CXCL8 is N-terminally processed to yield the major in vivo species, the 6-77 variant.
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