Human CXCL7 (NAP-2, neutrophil activating peptide-2) a 70-residue CXC chemokine encoded by the PPBP gene, is a potent neutrophil chemoattractant and activator, playing a pivotal role in inflammation, angiogenesis, and immune responses. Secreted primarily by activated platelets, CXCL7 bridges hemostasis and immunity by recruiting neutrophils to sites of injury or infection via CXCR2 receptors, while also exhibiting antimicrobial properties and contributing to tissue repair. Elevated in conditions like atherosclerosis, sepsis, and cancer, CXCL7 is a promising biomarker and therapeutic target for inflammatory and neoplastic diseases.
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