Description: Human CXCL5 is a 78 amino acid protein expressed by TNF- activated eosinophils and recruits CXCR2+ neutrophils to inflamed tissues. CXCL5 has been implicated as peripheral mediator of UVB-induced pain. Secreted full-length CXCL5 can be N-terminally truncated by leukocyte proteases to produce a 5-78 variant that is an 8-fold more potent chemoattractant than the full-length version.
Amino Acid Sequence:
AGPAAAVLRE LRCVCLQTTQ GVHPKMISNL QVFAIGPQCS KVEVVASLKN GKEICLDPEA PFLKKVIQKI LDGGNKEN
Purity assessed by HPLC, Mass Spectrometry, and NMR*
Human protein expressed in E. coli
Freely soluble in water **
-20C to -80C
Additional comments or descriptive information:
* All recombinant proteins produced and sold by Protein Foundry, LLC are endotoxin-free <0.01 EU/ug of protein and validated using RP-HPLC, 2D-NMR, and functional reporter assay where available.
** Avoid repeated freeze-thaw cycles after reconstitution