Human CXCL4 (Platelet Factor-4, PF-4), is a 70 amino acid protein that is released by activated platelets to promote coagulation. CXCL4 is scavenged by ACKR5 but does not activate any of the conventional chemokine receptors. It binds heparin and other glycosaminoglycans with high affinity and is a regulator of endothelial and homeopathic stem cell proliferation.
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