Human CXCL2(5-73) (C-X-C motif ligand 1(5-73); GRO-alpha(5-73)) is a 68 amino acid post-translationally modified version of an ELR+ chemokine that plays a key role in immune responses. It is primarily produced by macrophages, neutrophils, and other immune cells in response to infections or inflammatory stimuli. CXCL2 functions by binding to the CXCR2 receptor, attracting neutrophils to sites of infection or injury. CXCL2 also binds to the chemokine scavenger receptors ACKR1 and ACKR2. It is involved in processes such as wound healing, immune defense, and cancer progression. Dysregulation of CXCL2 has been linked to inflammatory diseases, cancer, and autoimmune disorders. CXCL2(5-73) is a more potent neutrophil chemoattractant than full length CXCL2.
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