Human CXCL12 gamma (stromal cell-derived factor 1 gamma, SDF-1 gamma), is an 88 residue isoform of CXCL12. A long C-terminal extension rich in basic residues adds strong heparin-binding properties that anchor it to tissues. Seven CXCL12 isoforms (alpha, beta, gamma, delta, etc.) arise due to alternative pre-mRNA splicing and vary mainly in tissue expression and the length and composition of a C-terminal sequence extension.
Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, Springer TA. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. 1996 Aug 29;382(6594):829-33. doi: 10.1038/382829a0. PMID: 8752280
Yu L, Cecil J, Peng SB, Schrementi J, Kovacevic S, Paul D, Su EW, Wang J. Identification and expression of novel isoforms of human stromal cell-derived factor 1. Gene. 2006 Jun 7;374:174-9. doi: 10.1016/j.gene.2006.02.001. Epub 2006 Apr 19. PMID: 16626895
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