Human CXCL11 (I-TAC, Interferon-inducible T-Cell alpha chemoattractant) is a 73 amino acid protein that binds CXCR3 and ACKR3. CXCL11 potently recruits Th1 lymphocytes and NK cells to sites of inflammation, playing a critical role in immune surveillance, antiviral responses, and tumor suppression. Of the chemokines that bind CXCR3, CXCL11 is the most potent, making it a key player in Th1-mediated immunity and a target for research in autoimmune diseases and cancer.
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