Human CCL21 (C-C motif ligand 21; also known as SLC, 6Ckine) is a 111-amino-acid CC chemokine with six conserved cysteines (vs. four in most CC chemokines), expressed in high endothelial venules, lymphatic endothelium, and stromal cells of lymphoid tissues. CCL21 binds CCR7 to direct naïve T cells, central memory T cells, and mature dendritic cells into lymph nodes and Peyer's patches. It also binds ACKR4, which scavenges CCL21 to shape gradients, and ACKR5. CCL21 is essential for lymph node architecture, adaptive immunity initiation, and cancer metastasis. These interactions highlight CCL21's non-redundant role in immune cell homing and lymphoid organogenesis.
Additional Notes:
View CartItems0
