Description: Human CCL2, also designated Monocyte chemotactic protein 1 (MCP-1), Monocyte chemotactic and activating factor (MCAF) and JE, chemoattracts mononuclear cells through activation of the G protein-coupled receptor CCR2. The N-terminal glutamine of CCL2 undergoes post-translational modification to pyroglutamic acid. Macrophages and monocytes are the primary producers of CCL2.
Amino Acid Sequence:
QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT
Purity assessed by HPLC, Mass Spectrometry, and NMR*
Human protein expressed in E. coli
Freely soluble in water **
-20C to -80C
Additional comments or descriptive information:
* All recombinant proteins produced and sold by Protein Foundry, LLC are endotoxin-free <0.01 EU/ug of protein and validated using RP-HPLC, 2D-NMR, and functional reporter assay where available.
** Avoid repeated freeze-thaw cycles after reconstitution