Human CCL15(25-92) (C-C motif ligand 15(25-92); also known as MIP-1γ(25-92), HCC-2(25-92)) is a 68-amino-acid N-terminally truncated CC chemokine generated by proteolytic activation of CCL15(1-92) via removal of the first 24 residues by neutrophil elastase, cathepsin G, or other proteases during inflammation. CCL15(25-92) is a highly potent agonist of CCR1 and CCR3, inducing robust chemotaxis of monocytes, T cells, and eosinophils, rheumatoid arthritis, and tumor progression. These interactions highlight CCL15(25-92)'s critical role in amplifying inflammatory responses.
Additional Notes:
View CartItems0
