CXCL12 Gamma Regulates Endothelial Cell Adhesion When Bound to Heparan
Posted by Mike Dwinell on 5/9/2025 to
Literature Highlights
CRISPR Edited Knockdown of CCL5 Enhances Antitumor Immune Responses CCL5 , originally called RANTES
(Regulated upon Activation, Normal T Cell Expressed and Presumably
CRISPR Edited Knockdown of CCL5 Enhances Antitumor Immune Responses
Posted by Mike Dwinell on 3/28/2025 to
Literature Highlights
CRISPR edited knockdown of CCL5 enhances antitumor immune responses
CCL5, originally called RANTES (Regulated upon
Deorphanization of GPR182 as Atypical Chemokine Receptor 5
Posted by Mike Dwinell on 11/12/2024 to
Literature Highlights
Characterization of GPR182 as a scavenging atypical chemokine receptor While G protein coupled receptor (GPCR) are one of the largest family of receptors, only 40% of the entire GPCR-ome has been targeted with therapeutic drugs. Efforts to
Structure-functions studies identify the CXCL14 receptor, MRGPRX2, on mast cells
Posted by Mike Dwinell on 6/16/2024 to
Literature Highlights
Identification of a receptor for the orphan chemokine CXCL14 CXCL14 was first characterized in 1999 by Hromas and colleagues and called BRAK following its initial isolation from breast and kidney cells. The Cxcl14 gene encodes a 99-amino acid
Anti-aging effects of the chemokines XCL1 and PF4 in the brain
Posted by Brian Volkman on 4/16/2024 to
Literature Highlights
When tech billionaires and other financial ‘masters of the universe’ types think about their own mortality, a significant number decide it simply isn’t for them. The result: huge investments in research to find the biochemical keys to unlock the
The immunoglobulin J chain is an evolutionarily co-opted chemokine
Posted by Mike Dwinell on 4/16/2024 to
Literature Highlights
Chemokines are a large family of soluble peptides guiding cell migration in development and
immune defense. They regulate immune cell migration, both under inflammatory and normal
physiological conditions through their cognate
Using chemokine receptors to improve cancer immunotherapy: CCR4-targeted T cell fratricide
Posted by Mike Dwinell on 1/22/2024 to
Literature Highlights
Chimeric antigen receptor T cell (CAR-T) therapy continues to be a powerful approach for treating relapsed-refractory hematological malignancies. Despite ongoing clinical success patients remain resistant to long-term benefits of CAR-T therapy.
Dendritic cell recruitment by the chemokine XCL1 improves cancer outcomes
Posted by Brian Volkman on 9/8/2023 to
Literature Highlights
XCL1 as a Potential Biomarker to Predict Durable Response to Anti-PD-1 Treatment in Non-Small Cell Lung Cancer XCL1 is secreted by activated T and NK cells. It is thought to function by promoting their engagement with antigen-presenting
Cooperative chemokine signaling influencing T cell movement from blood to tissue
Posted by Mike Dwinell on 5/19/2023 to
Literature Highlights
Chemokine positioning assists extravasation of pathogenic human T cells
CXCL12 potentiates chromatin compaction via ACKR3 activation
Posted by Brian Volkman on 1/6/2023 to
Literature Highlights
CXCL12 and its receptor CXCR4 have well known roles in bone marrow homing and
mobilization of hematopoietic stem cells and neutrophils, but inflammatory neutrophil
recruitment is governed by CXCR2 and its
