Modeling ligand-receptor specificity
Posted by Brian Volkman on 5/13/2020 to
Literature Highlights
Using a hybrid modeling approach, Fox generated a model for the chemokine XCL1 in complex with its G protein-coupled receptor XCR1 and identified key interaction sites. Changes within a region of XCL1 that determined its binding energy to XCR1 changed the activity of the receptor and,
consequently, cell migration