Origins of Metamorphism in XCL1

A new TiBS Spotlight features the work of Protein Foundry scientists and collaborators on the evolution of a highly unusual chemokine.
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Study reveals evolutionary origins of fold-switching protein

A shapeshifting immune system protein called XCL1 evolved from a single-shape ancestor hundreds of millions of years ago. Researchers at the Medical College of Wisconsin discovered the molecular basis for how this happened, in  a study
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Modeling ligand-receptor specificity

Using a hybrid modeling approach, Fox generated a model for the chemokine XCL1 in complex with its G protein-coupled receptor XCR1 and identified key interaction sites. Changes within a region of XCL1 that determined its binding energy to XCR1 changed the activity of the receptor and, consequently, cell migration
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