Origins of Metamorphism in XCL1
Posted by Brian Volkman on 4/6/2021 to
Recent Publications
A new TiBS Spotlight features the work of Protein Foundry scientists and collaborators on the evolution of a highly unusual chemokine.
Study reveals evolutionary origins of fold-switching protein
Posted by Brian Volkman on 1/9/2021 to
Recent Publications
A shapeshifting immune system protein called XCL1 evolved from a single-shape ancestor hundreds of millions of years ago. Researchers at the Medical College of Wisconsin discovered the molecular basis for how this happened, in a study
Modeling ligand-receptor specificity
Posted by Brian Volkman on 5/13/2020 to
Recent Publications
Using a hybrid modeling approach, Fox generated a model for the chemokine XCL1 in complex with its G protein-coupled receptor XCR1 and identified key interaction sites. Changes within a region of XCL1 that determined its binding energy to XCR1 changed the activity of the receptor and,
consequently, cell migration