Decoding the Selective Promiscuity of the Chemokine Network
Posted by Brian Volkman on 12/5/2025 to
Recent Publications
Unlocking the Code Behind Cell Migration Researchers at the Medical College of Wisconsin, Luxembourg Institute for Health and St. Jude Children’s Research Hospital have developed a data science framework that reveals how cells
Modulation of Acute Myelogenous Leukemia Cell Migration Through Altered CXCR4 Receptor Internalization
Posted by Mike Dwinell on 11/21/2025 to
Recent Publications
CXCL12 Dimers Stimulate Durable Receptor Desensitization Acute myelogenous leukemia (AML) is a heterogenous malignancy of adults and children
characterized by clonal expansion of immature myeloid blast cells
Introduction to Chemokines: What Are They?
Posted by Leyla Sutton on 9/5/2025 to
Learn About Chemokines
Characterization of GPR182 as a scavenging atypical chemokine receptor While G protein coupled receptor (GPCR) are one of the largest family of receptors, only 40% of the entire GPCR-ome has been targeted with therapeutic drugs. Efforts to
In the News: Protein Foundry Featured by MKE Startup News
Posted by Leyla Sutton on 8/8/2025 to
Protein Foundry News
Protein Foundry was featured in MKE Startup News, highlighting our growing role in Milwaukee’s expanding biotech landscape. The article, titled Protein Foundry: Milwaukee’s Medical Foundry, offers a closer look at how we support global biomedical research by producing high quality recombinant chemokines and cytokines for both academic and industrial use.
CXCL12 Gamma Regulates Endothelial Cell Adhesion When Bound to Heparan
Posted by Mike Dwinell on 5/9/2025 to
Literature Highlights
CRISPR Edited Knockdown of CCL5 Enhances Antitumor Immune Responses CCL5 , originally called RANTES
(Regulated upon Activation, Normal T Cell Expressed and Presumably
CRISPR Edited Knockdown of CCL5 Enhances Antitumor Immune Responses
Posted by Mike Dwinell on 3/28/2025 to
Literature Highlights
CRISPR edited knockdown of CCL5 enhances antitumor immune responses
CCL5, originally called RANTES (Regulated upon
Deorphanization of GPR182 as Atypical Chemokine Receptor 5
Posted by Mike Dwinell on 11/12/2024 to
Literature Highlights
Characterization of GPR182 as a scavenging atypical chemokine receptor While G protein coupled receptor (GPCR) are one of the largest family of receptors, only 40% of the entire GPCR-ome has been targeted with therapeutic drugs. Efforts to
Structure-functions studies identify the CXCL14 receptor, MRGPRX2, on mast cells
Posted by Mike Dwinell on 6/16/2024 to
Literature Highlights
Identification of a receptor for the orphan chemokine CXCL14 CXCL14 was first characterized in 1999 by Hromas and colleagues and called BRAK following its initial isolation from breast and kidney cells. The Cxcl14 gene encodes a 99-amino acid
The immunoglobulin J chain is an evolutionarily co-opted chemokine
Posted by Mike Dwinell on 4/16/2024 to
Literature Highlights
Chemokines are a large family of soluble peptides guiding cell migration in development and
immune defense. They regulate immune cell migration, both under inflammatory and normal
physiological conditions through their cognate
Anti-aging effects of the chemokines XCL1 and PF4 in the brain
Posted by Brian Volkman on 4/16/2024 to
Literature Highlights
When tech billionaires and other financial ‘masters of the universe’ types think about their own mortality, a significant number decide it simply isn’t for them. The result: huge investments in research to find the biochemical keys to unlock the
