Cyclic D-Sulfopeptide Ligands Lend Drug Development a Helping Hand
Posted by Francis Peterson on 4/2/2026 to
Literature Highlights
In their recent paper, Zhang and colleagues identified a 24-residue cyclic D –sulfopeptide inhibitor of CCL22, a chemokine associated with allergenic inflammation and atopic dermatitis.
From Optimal Gradients to Pathological Chaos
Posted by Brian Volkman on 3/13/2026 to
Literature Highlights
Researchers at the Albert Einstein College of Medicine and New York University use zebrafish to study cell migration in development and inflammation.
Introduction to Chemokines: What Are They Made Of?
Posted by Leyla Sutton on 3/3/2026 to
Learn About Chemokines
Chemokines are a family of small, secreted proteins whose purpose is to guide cell movement. Different chemokines direct cell movement in different ways depending on their structure, species of origin, and biological context.
To understand why chemokines behave differently, scientists first look at their structure.
The Complex Role of Heparan Sulfate in Regulating Inflammation
Posted by Mike Dwinell on 2/13/2026 to
Recent Publications
During inflammation, loss of heparan sulfate from the endothelial glycocalyx facilitates interactions with leukocytes, resulting in their recruitment to inflammatory sites. Adhesion molecules provide a molecular
Decoding the Selective Promiscuity of the Chemokine Network
Posted by Brian Volkman on 12/5/2025 to
Recent Publications
Unlocking the Code Behind Cell Migration Researchers at the Medical College of Wisconsin, Luxembourg Institute for Health and St. Jude Children’s Research Hospital have developed a data science framework that reveals how cells
Modulation of Acute Myelogenous Leukemia Cell Migration Through Altered CXCR4 Receptor Internalization
Posted by Mike Dwinell on 11/21/2025 to
Recent Publications
CXCL12 Dimers Stimulate Durable Receptor Desensitization Acute myelogenous leukemia (AML) is a heterogenous malignancy of adults and children
characterized by clonal expansion of immature myeloid blast cells
Introduction to Chemokines: What Are They?
Posted by Leyla Sutton on 9/5/2025 to
Learn About Chemokines
Characterization of GPR182 as a scavenging atypical chemokine receptor While G protein coupled receptor (GPCR) are one of the largest family of receptors, only 40% of the entire GPCR-ome has been targeted with therapeutic drugs. Efforts to
In the News: Protein Foundry Featured by MKE Startup News
Posted by Leyla Sutton on 8/8/2025 to
Protein Foundry News
Protein Foundry was featured in MKE Startup News, highlighting our growing role in Milwaukee’s expanding biotech landscape. The article, titled Protein Foundry: Milwaukee’s Medical Foundry, offers a closer look at how we support global biomedical research by producing high quality recombinant chemokines and cytokines for both academic and industrial use.
CXCL12 Gamma Regulates Endothelial Cell Adhesion When Bound to Heparan
Posted by Mike Dwinell on 5/9/2025 to
Literature Highlights
The chemokine family of immune modulators have pleiotropic functions explained in part by ligand–receptor redundancy, influence of glycosaminoglycans and atypical chemokine receptors (ACKR) on ligand gradients, alterations in gene expression, or discrete pharmacologic signaling.
CRISPR Edited Knockdown of CCL5 Enhances Antitumor Immune Responses
Posted by Mike Dwinell on 3/28/2025 to
Literature Highlights
CRISPR edited knockdown of CCL5 enhances antitumor immune responses
CCL5, originally called RANTES (Regulated upon
