Deorphanization of GPR182 as Atypical Chemokine Receptor 5
Posted by Mike Dwinell on 11/12/2024 to
Literature Highlights
Characterization of GPR182 as a scavenging atypical chemokine receptor While G protein coupled receptor (GPCR) are one of the largest family of receptors, only 40% of the entire GPCR-ome has been targeted with therapeutic drugs. Efforts to
Structure-functions studies identify the CXCL14 receptor, MRGPRX2, on mast cells
Posted by Mike Dwinell on 6/16/2024 to
Recent Publications
Identification of a receptor for the orphan chemokine CXCL14 CXCL14 was first characterized in 1999 by Hromas and colleagues and called BRAK following its initial isolation from breast and kidney cells. The Cxcl14 gene encodes a 99-amino acid
The immunoglobulin J chain is an evolutionarily co-opted chemokine
Posted by Mike Dwinell on 4/16/2024 to
Recent Publications
Chemokines are a large family of soluble peptides guiding cell migration in development and
immune defense. They regulate immune cell migration, both under inflammatory and normal
physiological conditions through their cognate
Anti-aging effects of the chemokines XCL1 and PF4 in the brain
Posted by Brian Volkman on 4/16/2024 to
Recent Publications
When tech billionaires and other financial ‘masters of the universe’ types think about their own mortality, a significant number decide it simply isn’t for them. The result: huge investments in research to find the biochemical keys to unlock the
Using chemokine receptors to improve cancer immunotherapy: CCR4-targeted T cell fratricide
Posted by Mike Dwinell on 1/22/2024 to
Recent Publications
Chimeric antigen receptor T cell (CAR-T) therapy continues to be a powerful approach for treating relapsed-refractory hematological malignancies. Despite ongoing clinical success patients remain resistant to long-term benefits of CAR-T therapy.
Solving the mystery of CXCL4's role in leukocyte recruitment
Posted by Brian Volkman on 11/21/2023 to
Recent Publications
Chemokine-matrix Interactions Promote Immune Cell Accumulation Independent of Chemokine Receptors The chemokine CXCL4 is also known as platelet factor 4 (PF4), because:
it is released from alpha-granules of activated
Dendritic cell recruitment by the chemokine XCL1 improves cancer outcomes
Posted by Brian Volkman on 9/8/2023 to
Literature Highlights
XCL1 as a Potential Biomarker to Predict Durable Response to Anti-PD-1 Treatment in Non-Small Cell Lung Cancer XCL1 is secreted by activated T and NK cells. It is thought to function by promoting their engagement with antigen-presenting
Crystal structure of CCL21 and identification of a sulfotyrosine binding site by NMR
Posted by Brian Volkman on 7/14/2023 to
Literature Highlights
Custom-made 15N-enriched CCL21 protein supplied by Protein Foundry The chemokine CCL21 guides both T cell and metastatic cancer homing to lymph nodes by activating the receptor CCR7. CCL21 is among a handful of chemokines with an unstructured
Protein Foundry’s CXCL4 used to identify antibodies that cause heparin-induced thrombocytopenia
Posted by Brian Volkman on 6/7/2023 to
Literature Highlights
Cloned antibodies from patients with heparin-induced thrombocytopenia (HIT) provide new clues to HIT pathogenesis A recent study published in Blood from scientists at @BloodCenterWI and @MayoClinic reveals structural differences between
Cooperative chemokine signaling influencing T cell movement from blood to tissue
Posted by Mike Dwinell on 5/19/2023 to
Literature Highlights
Chemokine positioning assists extravasation of pathogenic human T cells