Human CXCL10 identified as a risk factor for cardiovascular disease

Plasma concentrations of inflammatory proteins can serve as biomarkers for cardiovascular disease (CVD). Previous studies had linked the T cell chemokine CXCL10/IP-10 to hypertension and heart failure, but failed to achieve the statistical significance necessary for its use as a biomarker for human disease.
Read More

Human CXCL4 (PF4) linked to Covid-19 vaccine blood clots

As reported recently in the Wall Street Journal and other publications, the human chemokine CXCL4 (also known as platelet factor 4 or PF4) is the common link between COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) and a more common condition known as heparin-induced thrombocytopenia (HIT). 
Read More

Origins of Metamorphism in XCL1

A new TiBS Spotlight features the work of Protein Foundry scientists and collaborators on the evolution of a highly unusual chemokine.
Read More

Study reveals evolutionary origins of fold-switching protein

A shapeshifting immune system protein called XCL1 evolved from a single-shape ancestor hundreds of millions of years ago. Researchers at the Medical College of Wisconsin discovered the molecular basis for how this happened, in  a study
Read More

Modeling ligand-receptor specificity

Using a hybrid modeling approach, Fox generated a model for the chemokine XCL1 in complex with its G protein-coupled receptor XCR1 and identified key interaction sites. Changes within a region of XCL1 that determined its binding energy to XCR1 changed the activity of the receptor and, consequently, cell migration
Read More
TOP