Description: This construct contains the WT sequence for XCL2. A disulfide bond forms between C11 and C48. XCL2 differs from XCL1 by two amino acids at sequence positions 7 and 8. It has previously been shown that WT Lymphotactin (XCL2) is able to interconvert between two distinct conformations under physiological conditions. In one conformation, Lymphotactin exists as a monomer and is able to bind to its receptor, XCR1. In the other conformation, Lymphotactin exists as a dimer and loses its affinity for XCR1.
Amino Acid Sequence:
VGSEVSHRRT CVSLTTQRLP VSRIKTYTIT EGSLRAVIFI TKRGLKVCAD PQATWVRDVV RSMDRKSNTR NNMIQTKPTG TQQSTNTAVT LTG
Purity assessed by HPLC, Mass Spectrometry, and NMR*
Human protein expressed in E. coli
Freely soluble in water **
-20C to -80C
Additional comments or descriptive information:
* All recombinant proteins produced and sold by Protein Foundry, LLC are endotoxin-free <0.01 EU/ug of protein and validated using RP-HPLC, 2D-NMR, and functional reporter assay where available.
** Avoid repeated freeze-thaw cycles after reconstitution