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Recombinant human CXCL11 is secreted from cells after cleavage of the signal peptide to yield a 73 residue polypeptide. Human CXCL11, also known as Interferon Inducible T-Cell a, I-TAC, SCYB9B, H174 and beta -R1, is a ligand for the G protein coupled receptors CXCR3 and CXCR7 whose production is induced by interferon production. It is expressed in many cell types including peripheral blood leukocytes, pancreas and liver astrocytes. CXCL11 induces calcium release in activated T-cells and is chemotactic for interleukin-stimulated T-cells.
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