Description: Human CCL3, also known as Macrophage inflammatory protein-1 alpha (MIP-1alpha) and LD78, is closely related to CCL4/MIP-1beta. The biological activity of CCL3 is mediated through activation of the G protein-coupled receptors CCR1, CCR3 and CCR5. Human CCL3 is a potent chemoattractant for immature dendritic cells, T cells, NK cells, neutrophils, and eosinophils. CCL3 is also a known stem cell inhibitor that can inhibit the proliferation of hematopoietic progenitor cells.
Amino Acid Sequence:
Molecular Weight:
7741.3 Daltons
Fusion Tag:
N/A
Special Characteristic(s):
Purity:
Purity assessed by HPLC, Mass Spectrometry, and NMR*
Source:
Human protein expressed in E. coli
Physical Form:
Lyophilized
Solubility:
Freely soluble in water **
Storage Conditions:
Product Form
Temperature
Storage Time
-20C to -80C
12 months
4C
6 months
RT
1 month
Additional comments or descriptive information:
* All recombinant proteins produced and sold by Protein Foundry, LLC are endotoxin-free <0.01 EU/ug of protein and validated using RP-HPLC, 2D-NMR, and functional reporter assay where available.
** Avoid repeated freeze-thaw cycles after reconstitution
