Recombinant human CCL2 is secreted from cells after cleavage of the signal peptide. Human CCL2, also designated Monocyte chemotactic protein 1 (MCP-1), Monocyte chemotactic and activating factor (MCAF) and JE, chemoattracts mononuclear cells through activation of the G protein-coupled receptor CCR2. The N-terminal glutamine of CCL2 undergoes post-translational modification to pyroglutamic acid. Macrophages and monocytes are the primary producers of CCL2.
| Purity|| Assessed by HPLC, Mass Spectrometry, and NMR |
| Source|| Human protein expressed in E. coli|
| Physical form|| Lyophilized powder|
| Solubility|| Freely Soluble in Water|
| Accession #|| |
| N-terminal analysis || Lys22|
| Endotoxin level|| <0.01 EU per 1µg of the protein by LAL method|