Description: Recombinant human CCL1 is expressed in E. coli, refolded and purified to yield the 73 residue mature protein that is secreted from cells after cleavage of the signal peptide. Human CCL1, also designated T lymphocyte-secreted protein I-309 and TCA-3, chemoattracts monocytes and Th2 differentiated T-cells through activation of the G protein-coupled receptor CCR8. CCL1 plays an active role in bronchial asthma and atopic dermatitis.
Amino Acid Sequence:
KSMQVPFSRCCFSFAEQEIPLRAILCYRNTSSICSNEGLIFKLKRGKEACALD
TVGWVQRHRKMLRHCPSKRK
Molecular Weight:
8486.1 Daltons
Fusion Tag:
N/A
Special Characteristic(s):
Purity:
Purity assessed by HPLC, Mass Spectrometry, and NMR*
Source:
Human protein expressed in E. coli
Physical Form:
Lyophilized
Solubility:
Freely soluble in water **
Storage Conditions:
Product Form
Temperature
Storage Time
-20C to -80C
12 months
4C
6 months
RT
1 month
Additional comments or descriptive information:
* All recombinant proteins produced and sold by Protein Foundry, LLC are endotoxin-free <0.01 EU/ug of protein and validated using RP-HPLC, 2D-NMR, and functional reporter assay where available.
** Avoid repeated freeze-thaw cycles after reconstitution
