Description: Human CCL14, also known as Hemofiltrate CC Chemokine-1, HCC-1/HCC-3 and NCC-2, is a weak agonist of the G protein-coupled receptor CCR1. Proteolytic removal of the 8 N-terminal residues generates a 66 amino acid CCL14 variant that is a potent agonist of CCR1 and CCR5. The truncated CCL14 is a chemoattractant for T lymphocytes, monocytes, and eosinophils. It occurs at a 100- to 1,000-fold-lower concentration in human hemofiltrate than CCL14 1–74, when estimated from relative recovery during isolation.
Amino Acid Sequence:
GPYHPSECCF TYTTYKIPRQ RIMDYYETNS QCSKPGIVFI TKRGHSVCTN PSDKWVQDYI KDMKEN
Purity assessed by HPLC, Mass Spectrometry, and NMR*
Human protein expressed in E. coli
Freely soluble in water **
-20C to -80C
Additional comments or descriptive information:
* All recombinant proteins produced and sold by Protein Foundry, LLC are endotoxin-free <0.01 EU/ug of protein and validated using RP-HPLC, 2D-NMR, and functional reporter assay where available.
** Avoid repeated freeze-thaw cycles after reconstitution