CXCL12 potentiates chromatin compaction via ACKR3 activation
Posted by Brian Volkman on 1/6/2023 to
Recent Publications
CXCL12 and its receptor CXCR4 have well known roles in bone marrow homing and
mobilization of hematopoietic stem cells and neutrophils, but inflammatory neutrophil
recruitment is governed by CXCR2 and its
Chemokine CXCL4 key to rare COVID-19 vaccine side effect
Posted by Brian Volkman on 11/29/2021 to
Recent Publications
Chemokine CXCL4 key to rare COVID-19 vaccine side effect
Human CXCL10 identified as a risk factor for cardiovascular disease
Posted by Brian Volkman on 8/31/2021 to
Recent Publications
Plasma concentrations of inflammatory proteins can serve as biomarkers for cardiovascular disease (CVD). Previous studies had linked the T cell chemokine CXCL10/IP-10 to hypertension and heart failure, but failed to achieve the statistical significance necessary for its use as a biomarker for human disease.
Origins of Metamorphism in XCL1
Posted by Brian Volkman on 4/6/2021 to
Recent Publications
A new TiBS Spotlight features the work of Protein Foundry scientists and collaborators on the evolution of a highly unusual chemokine.
Study reveals evolutionary origins of fold-switching protein
Posted by Brian Volkman on 1/9/2021 to
Recent Publications
A shapeshifting immune system protein called XCL1 evolved from a single-shape ancestor hundreds of millions of years ago. Researchers at the Medical College of Wisconsin discovered the molecular basis for how this happened, in a study
Modeling ligand-receptor specificity
Posted by Brian Volkman on 5/13/2020 to
Recent Publications
Using a hybrid modeling approach, Fox generated a model for the chemokine XCL1 in complex with its G protein-coupled receptor XCR1 and identified key interaction sites. Changes within a region of XCL1 that determined its binding energy to XCR1 changed the activity of the receptor and,
consequently, cell migration