CXCL12 potentiates chromatin compaction via ACKR3 activation

CXCL12 and its receptor CXCR4 have well known roles in bone marrow homing and  mobilization of hematopoietic stem cells and neutrophils, but inflammatory neutrophil  recruitment is governed by CXCR2 and its
Read More

Chemokine CXCL4 key to rare COVID-19 vaccine side effect

Chemokine CXCL4 key to rare COVID-19 vaccine side effect
Read More

Human CXCL10 identified as a risk factor for cardiovascular disease

Plasma concentrations of inflammatory proteins can serve as biomarkers for cardiovascular disease (CVD). Previous studies had linked the T cell chemokine CXCL10/IP-10 to hypertension and heart failure, but failed to achieve the statistical significance necessary for its use as a biomarker for human disease.
Read More

Origins of Metamorphism in XCL1

A new TiBS Spotlight features the work of Protein Foundry scientists and collaborators on the evolution of a highly unusual chemokine.
Read More

Study reveals evolutionary origins of fold-switching protein

A shapeshifting immune system protein called XCL1 evolved from a single-shape ancestor hundreds of millions of years ago. Researchers at the Medical College of Wisconsin discovered the molecular basis for how this happened, in  a study
Read More

Modeling ligand-receptor specificity

Using a hybrid modeling approach, Fox generated a model for the chemokine XCL1 in complex with its G protein-coupled receptor XCR1 and identified key interaction sites. Changes within a region of XCL1 that determined its binding energy to XCR1 changed the activity of the receptor and, consequently, cell migration
Read More
TOP