Chemokine CXCL4 key to rare COVID-19 vaccine side effect

Chemokine CXCL4 key to rare COVID-19 vaccine side effect
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Human CXCL10 identified as a risk factor for cardiovascular disease

Plasma concentrations of inflammatory proteins can serve as biomarkers for cardiovascular disease (CVD). Previous studies had linked the T cell chemokine CXCL10/IP-10 to hypertension and heart failure, but failed to achieve the statistical significance necessary for its use as a biomarker for human disease.
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Origins of Metamorphism in XCL1

A new TiBS Spotlight features the work of Protein Foundry scientists and collaborators on the evolution of a highly unusual chemokine.
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Study reveals evolutionary origins of fold-switching protein

A shapeshifting immune system protein called XCL1 evolved from a single-shape ancestor hundreds of millions of years ago. Researchers at the Medical College of Wisconsin discovered the molecular basis for how this happened, in  a study
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Modeling ligand-receptor specificity

Using a hybrid modeling approach, Fox generated a model for the chemokine XCL1 in complex with its G protein-coupled receptor XCR1 and identified key interaction sites. Changes within a region of XCL1 that determined its binding energy to XCR1 changed the activity of the receptor and, consequently, cell migration
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