Posted by Brian Volkman on 7/20/2021 to
Application Note
As reported recently in the Wall Street Journal and other publications, the human chemokine CXCL4 (also known as platelet factor 4 or PF4) is the common link between COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) and a more common condition known as heparin-induced thrombocytopenia (HIT). Both syndromes involve the generation of antibodies targeting molecular complexes containing PF4. Lab tests that use a heparin-based ELISA may not detect those antibodies and a PF4-enhanced functional assay is required to diagnose either HIT or VITT with the greatest reliability.
Protein Foundry manufactures the highest quality recombinant human PF4/CXCL4 protein, which has been used in the development of the new gold-standard in vitro diagnostic test for HIT (Retham Technologies).
