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Human CXCL4 (PF4) linked to Covid-19 vaccine blood clots
Posted by Brian Volkman on 7/20/2021 to
Application Note
As reported recently in the Wall Street Journa
l and other publications, the human chemokine CXCL4 (also known as platelet factor 4 or PF4) is the common link between COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) and a more common condition known as heparin-induced thrombocytopenia (HIT). Both syndromes involve the generation of antibodies targeting molecular complexes containing PF4. Lab tests that use a heparin-based ELISA may not detect those antibodies and a
PF4-enhanced functional assay is required to diagnose either HIT or VITT with the greatest reliability.
Protein Foundry manufactures the highest quality recombinant human
PF4/CXCL4 protein
, which has been used in the development of the new gold-standard in vitro diagnostic test for HIT (Retham Technologies).
Anand Padmanabhan on LinkedIn: Thrombic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination | NEJM
Retham Technologies seeks to revolutionize the diagnosis of Heparin induced thrombocytopenia (HIT) by enabling rapid and accurate testing
Recombinant hCXCL4
Check out our full catalog of high-quality native chemokines.
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Recombinant hCXCL4 with C-terminal label
The product is shown with with a 647 nm fluorescent label.
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