Human Human XCL2(1-93) (SCM-2) is a C chemokine with a mature secreted polypeptide of 93 amino acids that differs from human XCL1 at only two sequence positions. Unlike CXC or CC chemokines, its structure lacks two of the four conserved cysteine residues, resulting in a single disulfide bond and a less stable chemokine fold that interconverts with an unrelated all-beta sheet dimeric structure. XCL2 is secreted by activated CD8+ T and NK cells and binds to the XCR1 receptor, primarily attracting cross-presenting dendritic cells (cDC1s), to orchestrate adaptive immune responses, especially in antiviral and antitumor immunity.
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