Description: Human CCL4, also designated Macrophage inflammatory protein-1 beta (MIP-1beta), T-cell activation protein 2 (ACT-2) and HC21, is proteolytically processed by CD26 to remove the two N-terminal residues. Full-length and proteolytically processed CCL4 activate the G protein-coupled receptors CCR5. Truncated for CCL4 also activates CCR1 and CCR2b. Human CCL4 is a potent chemoattractant for macrophages, NK cells, and lymphocytes.
Amino Acid Sequence:
APMGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRSKQ
VCADPSESWVQEYVYDLELN
Molecular Weight:
7814.2 Daltons
Fusion Tag:
N/A
Special Characteristic(s):
Purity:
Purity assessed by HPLC, Mass Spectrometry, and NMR*
Source:
Human protein expressed in E. coli
Physical Form:
Lyophilized
Solubility:
Freely soluble in water **
Storage Conditions:
Product Form
Temperature
Storage Time
-20C to -80C
12 months
4C
6 months
RT
1 month
Additional comments or descriptive information:
* All recombinant proteins produced and sold by Protein Foundry, LLC are endotoxin-free <0.01 EU/ug of protein and validated using RP-HPLC, 2D-NMR, and functional reporter assay where available.
** Avoid repeated freeze-thaw cycles after reconstitution
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