Description: Human CCL3, also known as Macrophage inflammatory protein-1 alpha (MIP-1alpha) and LD78, is closely related to CCL4/MIP-1beta. The biological activity of CCL3 is mediated through activation of the G protein-coupled receptors CCR1, CCR3 and CCR5. Human CCL3 is a potent chemoattractant for immature dendritic cells, T cells, NK cells, neutrophils, and eosinophils. CCL3 is also a known stem cell inhibitor that can inhibit the proliferation of hematopoietic progenitor cells.
Amino Acid Sequence:
|ASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV |
IFLTKRSRQV CADPSEEWVQ KYVSDLELSA
Purity assessed by HPLC, Mass Spectrometry, and NMR*
Human protein expressed in E. coli
Freely soluble in water **
-20C to -80C
Additional comments or descriptive information:
* All recombinant proteins produced and sold by Protein Foundry, LLC are endotoxin-free <0.01 EU/ug of protein and validated using RP-HPLC, 2D-NMR, and functional reporter assay where available.
** Avoid repeated freeze-thaw cycles after reconstitution